Abstract In this study, a composite of bioactive glass (BG) and cordierite (BG-cord) was proposed to increase the strength and bioactivity of BG. Both BG and cordierite were separately synthesized with the method of glass melting, then, they were used to fabricate BG-cord with a variation of sintering temperature (600 to 1000 °C). The highest diametral tensile strength (DTS=30.54 MPa) was shown by the BG-cord with sintering temperature at 925 ºC. Bioactivity tests were conducted by soaking in Hank’s balanced salt solution (HBSS) for 7, 14, and 21 days. Apatite formation was examined by using a scanning electron microscope. The results showed that the sample showed good bioactivity with regards to the formation of apatite on the samples, confirmed by the detection of carbonate (C-O) and phosphate (P-O) absorption peaks by Fourier transform infrared spectroscopy and crystalline peaks in the X-ray diffraction pattern.

Los hallazgos de varios estudios sugieren que la interacción de la acetilcolina (ACh) y la 5-hidroxitriptamina (5-HT) participa en la regulación de procesos fisiológicos y conductuales tales como la secreción del factor liberador de corticotropina y la memorización. En el presente trabajo se estudió el efecto del diisopropilfluorofosfato (DFP), un inhibidor irreversible de la acetilcolinesterasa, sobre los niveles de 5-HT y del ácido 5-hidroxiindolacético (5-HIAA) en seis regiones cerebrales de rata adulta. Las concentraciones de la monoamina y de su metabolito fueron medidas por cromatografía líquida de alta eficiencia (HPLC). El DFP disminuyó los niveles de 5-HIAA en el hipotálamo, sin modificación de los niveles de 5-HT. En el resto de las regiones, no se encontró modificación de los niveles de 5-HT ni de 5-HIAA.

A number of studies suggest that acetylcholine (ACh) and 5-hydroxytryptamine (5-HT) interrelationship participate on the regulation of physiological and behavioral processes like secretion of corticotropin releasing factor and memory function. The effects of diisopropyl fluorophosphate (DFP), an irreversible inhibitor of acetylcholinesterase, upon the 5-HT and 5-hydroxyindol acetic acid (5-HIAA) levels in six brain regions of the adult rat were studied. The concentration of monoamine and its metabolite were determined by high pressure liquid chromatography (HPLC). The relation metabolite/neurotransmitter was employed as an indicator of neuronal activity. The results indicate that DFP decreased the 5-HIAA levels in hypothalamus, without any modification on the 5-HT levels. In the other brain regions, it was not any change either on 5-HIAA or 5-HT levels.